Subtrochanteric Fracture

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An increasing number of case reports describe women with long-term bisphosphonate therapy who develop fractures involving the subtrochanteric or shaft region of the femur, considered atypical because of their location and characteristic appearance on x-rays. These Fractures Have Several Atypical Characteristics: Prodromal Symptoms, Occurrence With Minimal Trauma, Distinctive Radiographic Changes The three case reports earlier this year suggested that a common factor in patients with subtrochanteric or proximal diaphyseal fractures of the femur is alendronate use, Dr. Abrahamsen said. But those reports did not have any comparison data, he said. The U.S. Food and Drug Administration has ruled out a suggested link between bisphosphonate use and risk for atypical subtrochanteric femur fractures. “Recent news reports have raised the question about whether there is an increased risk in this type of Furthermore, the results suggested that cases of osteonecrosis of the jaw were associated with intravenous bisphosphonates, atypical Subtrochanteric Fracture was associated with longer duration of bisphosphonate treatment, and denosumab was associated with Bisphosphonates help prevent progressive bone mineralization loss and subsequent osteoporotic fractures. However, long-term bisphosphonate therapy paradoxically increases the risk of a unique injury called an atypical subtrochanteric femur fracture. .

We reviewed fracture records and radiographs (when available) from all hip and femur fractures to identify those below the lesser trochanter and above the distal metaphyseal flare (subtrochanteric and diaphyseal femur fractures) and to assess atypical The FDA has notified healthcare professionals and patients that at this point, the data that have been reviewed have not shown a clear connection between bisphosphonate use and a risk of atypical subtrochanteric femur fractures. The FDA will continue to .

Another Picture of Subtrochanteric Fracture :


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